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Turning off the disease (hemophilia) is caused when a defective gene inhibits the production of a protein essential blood clotting australian history process. Treatments for this disease and other genetic diseases involving dangerous blood transfusions or expensive enzyme replacement therapy. Prof. Yair Reisner, head of the Department of Immunology at the Weizmann Institute australian history of Science, graduate student Anna Aharonovitz, and other partners to research, have shown recently that healthy tissue transplantation of spleen (which produced some of the proteins australian history essential for blood clotting) can cause the body to produce its own these proteins. This study was published in the journal "entries National Academy of Sciences", Proceedings.
Previous attempts transplanted spleen tissue were unsuccessful because this organ are a lot of T cells of the immune system. These cells exert a strong rejection of the implant against the receiving body. Prof. Reisner and his team heads attempted to overcome australian history this difficulty unusual way. For several years they are exploring possibilities and ways to transplant tissue from fetal pigs, as a substitute for possible donations of human organs. They found that each type of organ, there is a window of opportunity, where chances of successful transplantation of fetal tissue - especially high. Fetal tissue transplantation too early development phase, when the cells have not yet begun to differentiate, can cause the development of tumors. On the other hand, fetal tissue transplants too late developmental stage may result in rejection of the implant by the body's immune system receiver. Prof. Reisner and his team discovered the exact timing embryonic australian history tissue develops will be the smallest risk of cancer, while not inspire too strong rejection of the receiving body. It turns out that every organ has developed its own unique window of opportunity in which the probability of success of its implantation are greatest. In the current study, scientists found the cells from which the future of pig embryos develop australian history spleen, by December 42 of pregnancy, yet there are no T cells that may thwart the transplantation australian history of these cells. They also found these cells transplant this window of time spleen tissue leading to a working australian history body of the recipient. This tissue successfully produces essential blood clotting protein, whose absence causes the disease bleeding. Mice with bleeding and tissue transplantation australian history from embryos australian history were swinish aged 42 days, developed within a month or two after transplantation of normal clotting ability of blood. How to implement this system in humans is still long and strewn with obstacles, but this experiment the Weizmann Institute of Science proves that this approach, a well-timed transplantation of tissue from fetal pigs may be applied to future people. In fact, the experiment revealed the transplanted fetal tissue appropriate time window produces a number of enzymes and other proteins disadvantage or harm each other genetic australian history disease causes. Therefore, scientists believe their ovaries to be performed by this method may help in overcoming various genetic diseases. This study was carried out with the support of "Tissera".
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